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Novel Caprolactones from a Marine Streptomycete

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Citation:
Stritzke, K. , Schulz, S. , Laatsch, H. , Helmke, E. and Beil, W. (2004): Novel Caprolactones from a Marine Streptomycete , Journal of natural products, 67 , pp. 395-401 . doi: 10.1021/np030321z
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Abstract:

Abstract:Two new caprolactones, (R)-10-methyl-6-undecanolide (1) and (6R,10S)-10-methyl-6-dodecanolide (2), were identified in thelipid extract of a marine streptomycete (isolate B6007). Their structures were proposed on the basis of GC-MS experimentsand proved by synthesis. The absolute configuration of the compounds was established by comparison of the natural andsynthetic stereoisomers using chiral gas chromatography. These caprolactones show a moderate phytotoxicity and apromising activity against cancer cells with concomitant low general cytotoxicity.

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