Macroozoobenthos plays an important role in tropical seagrasss beds. Many shredders of plant material, detritus feeders and decomposers can be found within this group. However, their distribution and biodiversity in Indonesian seagrass beds is widely unknown. In the present study, we investigated the distribution of macrozoobenthos in wet and dry season 2005. Four locations on a transect from inshore to off-shore conditions in the Spermonde archipelago, South Sulawesi, Indonesia were chosen.Siltation and percentage of terrigenous sediment decreased along this transect. The middle stations (Pulau Barang Lompo and Pulau Sarapokeke) were small islands with very high population densities. Therefore, the stress on local ecosystems in those locations could be considered high. On the other side, the inshore (Puntondo village) and off-shore locations (Pulau Kapoposang) sustained a small population and natural ecosystems remained relatively undisturbed.