We present a 3-D crustal model of the East Greenland Fjord Region between 69°N and 74°N. The model covers the Precambrian shield and the Caledonian orogenic belt, the adjoining Devonian and Mesozoic basins, the continent-ocean transition and the Cenozoic oceanic areas as far as the Kolbeinsey and the Mohns mid-oceanic ridges. Existing seismic models of the crustal structure are extrapolated into adjacent areas using 3-D gravity modelling. For this purpose, we compile a new regional-scale Bouguer anomaly map. The Precambrian shield, west of the Caledonian orogen (approximately west of 32°W), shows a mean thickness of 35 km with only small-scale undulations. This thickness is at the lower limit of the global range in shield thickness. The Caledonian orogen exhibits a pronounced mountain root with overall crustal thicknesses up to 51 km. Beside the Urals, the East Greenland Caledonides are one of the two Palaeozoic mountain belts where a crustal root has preserved to the present day. Continuation of the crustal model to the east, beyond the continent-ocean transition, yielded thicknesses of the crystalline oceanic crust from 9 km near the Kolbeinsey Ridge to 3 km west of the Mohns Ridge. Differences in the thermal structures of the old continental and the young oceanic lithosphere are responsible for the low-density mantle beneath the oceanic crust, which is also demonstrated by 3-D gravity modelling.