Perspectives on the synthesis and use of ageladine A


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Ulf.Bickmeyer [ at ] awi.de

Abstract

Focusing on the marine-derived alkaloid ageladine A ([4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4, 5-c]pyridin-2-amine trifluoroacetate), we combined and modified published strategies to develop a synthesis method with easily managed reaction steps that allows gram-scale batch synthesis. On exploration additional features of the fluorescent properties of the compound were revealed. In tissues and cells of a marine flatworm, the emission profile shifted to longer wavelengths than in water. The fluorescence emission maximum shifted around 30–450 nm and the profile showed sufficient intensity at approximately 550 nm and above



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ISI/Scopus peer-reviewed
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Published
Eprint ID
38234
DOI 10.1016/j.tetlet.2015.05

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Mordhorst, T. and Bickmeyer, U. (2015): Perspectives on the synthesis and use of ageladine A , Tetrahedron Letters, 56 , pp. 4363-4366 . doi: 10.1016/j.tetlet.2015.05


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