Temporal variations of the radionuclide 10Be are broadly synchronous across the globe and thus provide a powerful tool to synchronize ice core chronologies from different locations. We compared the 10Be record of the Akademii Nauk (AN) ice core (Russian Arctic) for the time period CE 1590–1950 to the 10Be records of two well-dated Greenland ice cores (Dye3 and NGRIP). A high correlation (r = 0.59) was found between the AN and Dye3 records whereas the correlation with NGRIP was distinctly lower (r = 0.45). Sources of deviations may include local fluctuations in the deposition of 10Be due to changes in the precipitation patterns, and artefacts due to the core-sampling strategy. In general, the existing age model was validated, confirming the AN ice core to be a unique and welldated source of palaeoclimate parameters for the Russian Arctic. We further used numerical simulations to test the influence of the core-sampling strategy on the results and derived an optimized sampling strategy for the deeper parts of the ice core.