The genus Alexandrium (Halim) is perhaps the most intensively studied among toxic marine dinoflagellates. This is largely attributable to the devastating consequences of toxigenic blooms of this genus, with human poisonings from contaminated seafood, primarily from shellfish and more rarely from finfish; socio–economic losses to the aquaculture and fisheries industries; marine faunal mortalities; and food web disruptions common in coastal waters throughout the world. Members of this genus are globally distributed from the Arctic to the tropics, and in both hemispheres from sub–polar through temperate to sub–tropical to tropicalwaters. At least four distinct groups of marine phycotoxins are associated with various Alexandrium species, along with poorly characterized bioactive compounds (allelochemicals) that may affect species interactions among the plankton. According to the most recent iteration of the IOC–UNESCO reference list of toxic microalgae, there are now more than 30 recognized morphological species of Alexandrium, posing a daunting challenge for risk assessment and accurate identification in toxic phytoplankton monitoring programs.