Causal explanations for the 4.2 ka BP event are based on the amalgamation of seasonal and annual records of climate variability that was manifest across global regions dominated by different climatic regimes. However, instrumental and paleoclimate data indicate that seasonal climate variability is not always sequential in some regions. The present study investigates the spatial manifestation of the 4.2 ka BP event during the boreal winter season in Eurasia, where climate variability is a function of the spatiotemporal dynamics of the westerly winds. We present a multi-proxy reconstruction of winter climate conditions in Europe, west Asia, and northern Africa between 4.3 and 3.8 ka. Our results show that, while winter temperatures were cold throughout the region, precipitation amounts had a heterogeneous distribution, with regionally significant low values in W Asia, SE Europe, and N Europe and local high values in the N Balkan Peninsula, the Carpathian Mountains, and E and NE Europe. Further, strong northerly winds were dominating in the Middle East and E and NE Europe. Analyzing the relationships between these climatic conditions, we hypothesize that in the extratropical Northern Hemisphere, the 4.2 ka BP event was caused by the strengthening and expansion of the Siberian High, which effectively blocked the moisture-carrying westerlies from reaching W Asia and enhanced outbreaks of cold and dry winds in that region. The behavior of the winter and summer monsoons suggests that when parts of Asia and Europe were experiencing winter droughts, SE Asia was experiencing similar summer droughts, resulting from failed and/or reduced monsoons. Thus, while in the extratropical regions of Eurasia the 4.2 ka BP event was a century-scale winter phenomenon, in the monsoon-dominated regions it may have been a feature of summer climate conditions.