• Browse
    • Author
    • Year
    • Platform
    • Organizations
    • Programs
    • Research Networks
    • Type
  • Search
    • Simple
    • Advanced
  • About
    • About
    • Policies
    • Citation Guide
  • Login
    Logo Alfred Wegener Institut
    Logo Alfred Wegener Institut
    Alfred-Wegener-Institut
    Helmholtz-Zentrum für Polar-
    und Meeresforschung
    • Imprint
    • Contact
    • OAI
    • RSS 2.0

    EPIC.awi.de

    Home
    • Browse
      • Author
      • Year
      • Platform
      • Organizations
      • Programs
      • Research Networks
      • Type
    • Search
      • Simple
      • Advanced
    • About
      • About
      • Policies
      • Citation Guide
    • Login
      Login

      Hydrogen Bonds and the Catalytic Mechanism of Human Carbonic Anhydrase II

      Edit Item Edit Item

      General Information:

      Citation:
      Thoms, S. (2002): Hydrogen Bonds and the Catalytic Mechanism of Human Carbonic Anhydrase II , Journal of theoretical biology , 215 (4), pp. 399-404 . doi: 10.1006/jtbi.2002.2528
      Cite this page as:
      hdl:10013/epic.15666
      DOI:
      https://doi.org/10.1006/jtbi.2002.2528
      Official URL:
      https://doi.org/10.1006/jtbi.2002.2528
      Contact Email:
      sthoms@awi-bremerhaven.de
      Related Data:

      Abstract:

      A new model for catalysis of human carbonic anhydrase II issuggested. The model is based on theX-ray structure of the hydrogen bond network in the catalyticsite. The outer part of the network is proposed to adjustthe pKa of the catalytic site to theexperimentally observed value of about 7.The inner part of the network is proposed to become a low-barrierhydrogen bond network in the transition state.The energy released in forming the low-barrier hydrogen bondnetwork is used to catalyze the interconversion of CO2 and HCO3-.The suggested molecular mechanism is consistent with thegenerally accepted kinetic schemefor human carbonic anhydrase II.

      Further Details:

      Item Type:
      Article
      Authors:
      Thoms, Silke
      Divisions:
      AWI Organizations > Biosciences > Junior Research Group: Carbon cycle
      AWI Organizations > Biosciences > BioGeoScience
      Programs:
      Basic Research > Helmholtz Independent Research
      Eprint ID:
      5099
      Logo Alfred Wegener Institut
      Alfred-Wegener-Institut
      Helmholtz-Zentrum für Polar-
      und Meeresforschung
      Logo Helmholtz

      • Browse
        • Author
        • Year
        • Platform
        • Organizations
        • Programs
        • Research Networks
        • Type
      • Search
        • Simple
        • Advanced
      • About
        • About
        • Policies
        • Citation Guide
      • Imprint
      • Contact
      • OAI
      © Alfred-Wegener-Institut