CO2 induced pHi changes in the brain of polar fish: a TauCEST application


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Felizitas.Wermter [ at ] awi.de

Abstract

Chemical exchange saturation transfer from taurine to water (TauCEST) is primarily detectable in the low temperature range. Since, TauCEST asymmetry is bijective in the physiological pH-range (6.8-7.5), TauCEST is a potential candidate for in vivo studies on brain of polar fish. The specificity of TauCEST MRI on the brain of polar cod at 1.5°C shows a taurine contribution of 65%. TauCEST in brain of polar cod significantly increased under elevated CO2 concentrations by about 1.34%-3.17% in comparison to control, reflecting pHi changes since localized 1H NMR spectra show no significant changes in metabolite concentration for the different treatments.



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Conference (Conference paper)
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Not peer-reviewed
Publication Status
Published
Event Details
Joint Annual Meeting ISMRM-ESMRMB, 16 Jun 2018 - 21 Jun 2018, Paris, France.
Eprint ID
51195
Cite as
Wermter, F. C. , Maus, B. , Pörtner, H. O. , Dreher, W. and Bock, C. (2018): CO2 induced pHi changes in the brain of polar fish: a TauCEST application , Joint Annual Meeting ISMRM-ESMRMB, Paris, France, 16 June 2018 - 21 June 2018 .


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