The evolution of halocline waters in the Makarov Basin and along the East Siberian continental slope is examined by combining drifting platform observations, shipborne hydrographic data, and simulations from a global operational physical model from 2007 to 2020. From 2012 onwards, relatively shallow and cold Atlantic-derived lower halocline waters, previously restricted to the Lomonosov Ridge area, progressed eastward along the East Siberian continental slope. Their eastward extent abruptly shifted from 155°E to 170°E in early 2012, stabilized at 170°E until the end of 2015, then gradually advanced to reach the western Chukchi Sea in 2017. Such eastward progression led to a strengthening of the associated boundary current and to the shedding of mesoscale eddies of cold Atlantic-derived waters into the lower halocline of the Makarov Basin in September 2015 and near the East Siberian continental slope in November 2017. Additionally, active mixing between upwelled Atlantic Water and shelf water formed dense warm water supplying the Makarov Basin lower halocline. The increasing contribution from Atlantic-derived waters into the lower halocline along the East Siberian continental slope and in the Makarov Basin led to a weakening of the halocline, which is characteristic of a new Arctic Ocean regime that started in the early 2000s in the Eurasian Basin. Our results suggest that this new Arctic regime may now extend toward the Amerasian Basin.