To validate the atmospheric general circulation models ECHAM5-wiso and ECHAM6-wiso with embedded water isotopic modules, nudging mode simulations were performed to known fields of temperature, pressure, wind speed and direction derived from retrospective climate analysis. The simulation results are compared with data on the isotopic composition (δHDO and δH218O) of water vapor in atmospheric air near the surface received at two monitoring stations: in Labytnangi (66.660° N, 66.409° E) and in Igarka (67.453° N, 86.535° E). The superiority of the newer model ECHAM6-wiso could not be unambiguously concluded, because the results of simulation in this model show a better agreement with data from Igarka, while the model ECHAM5-wiso shows a better agreement with the data measured in Labytnangi. The simulation results can be used as an a priori ensemble for the solution of the inverse problems of remote atmospheric sensing in western Siberia.