In the Fram Strait, mid-ocean ridge spreading is represented by the ultra-slow system of the Molloy Ridge, the Molloy Transform Fault and the Knipovich Ridge. Sediments on oceanic and continental crust are gas charged and there are several locations with documented seafloor seepage. Sedimentary faulting shows recent stress release in the sub-surface, but the drivers of stress change and its influence on fluid flow are not entirely understood. We present here the results of an 11-month-long ocean bottom seismometer survey conducted over the highly faulted sediment drift northwards from the Knipovich Ridge to monitor seismicity and infer the regional state of stress. We obtain a detailed earthquake catalog that improves the spatial resolution of mid-ocean ridge seismicity compared with published data. Seismicity at the Molloy Transform Fault is occurring southwards from the bathymetric imprint of the fault, as supported by a seismic profile. Earthquakes in the northern termination of the Knipovich Ridge extend eastwards from the ridge valley, which together with syn-rift faulting identified in seismic reflection data, suggests that a portion of the currently active spreading center is buried under sediments away from the bathymetric expression of the rift valley. This hints at the direct link between crustal rifting processes and faulting in shallow sediments. Two earthquakes occur close to the seepage system of the Vestnesa Ridge further north from the network. We suggest that deeper rift structures, reactivated by gravity and/or post-glacial subsidence, may lead to accommodation of stress through shallow extensional faults, therefore impacting seepage dynamics.