A main source of regional climate change uncertainty is the large disparity across models in simulating the atmospheric circulation response to global warming. Using the latest suite of global climate models from the sixth phase of the Coupled Model Intercomparison Project (CMIP6), a storyline approach is adopted to derive physically plausible scenarios of Antarctic climate change for 2070–99, according to Shared Socioeconomic Pathway SSP5-8.5. These storylines correspond to differences in the simulated amount of seasonal sea ice loss and either (i) the delay in the summertime stratospheric polar vortex (SPV) breakdown or (ii) wintertime SPV strengthening, which together constitute robust drivers of the response pattern to future climate change. Such changes combined are known to exert a strong control over the Southern Hemisphere midlatitude jet stream, which we quantify as collectively explaining up to 70% of the variance in jet response in summer and 35% in winter. For summer, the expected strengthening and displacement of the tropospheric jet stream varies between a;1 and 2 m s21 increase and;28–48 poleward shift, respectively, across storylines. In both seasons, a larger strengthening of the jet is correlated with less Antarctic warming. By contrast, the response in precipitation is more consistent but still strongly attenuated by large-scale dynamics. We find that an increase in high-latitude precipitation around Antarctica is more pronounced for storylines characterized by a greater poleward jet shift, particularly in summer. Our results highlight the usefulness of the storyline approach in illustrating model uncertainty and understanding the processes that determine the spread in projected Antarctic regional climate response. SIGNIFICANCE STATEMENT: Uncertainty in future climate predictions for the Antarctic is dominated by the unknown response of the large-scale (global) atmospheric circulation. In characterizing such uncertainty, plausible outcomes of climate response (storylines) are generated from the organization of model projections according to the amount of simulated seasonal sea ice loss and the delay in summertime breakdown/winter strengthening of the stratospheric westerly circulation (polar vortex). The intensity and location of the tropospheric jet stream is strongly dependent on both factors, which strongly influences the near-surface climate response over Antarctica. We find that the simulated amount that Antarctic air temperatures increase by in the future (to the end of the century) is intrinsically related to the projected intensification of the Southern Hemisphere tropospheric jet, varying by a factor of 2 or more across storylines for summer. Storylines with greater jet strengthening are associated with less Antarctic warming (reduced poleward advection of air masses from lower latitudes). Similar differences are found for changes in jet position, which we note has a much stronger control on mid- to high-latitude precipitation response. This includes both an enhanced wetting response around Antarctica and drying response farther equatorward, for storylines characterized by a greater poleward jet shift.