The Montreal‐Kunming Global Biodiversity Framework (GBF) substantially advances biodiversity protection. We systematically reviewed the scholarly literature published during the UN Decade on Biodiversity (2010–2020) to assess whether GBF targets align with scientific approaches and improve upon the Aichi Targets in recognizing the complexity of marine biodiversity. Our findings showed that the new targets have improved to address the full suite of essential biodiversity variable (EBV) classes, reducing the risk of changes in crucial aspects of biodiversity being overlooked. We observed a high degree of alignment between research and policy in EBVs and a relative increase in the reliance of the GBF on secondary variables such as ecosystem function. While this alignment mirrors that within other global frameworks, we caution against overemphasizing secondary variables at the expense of foundational variables such as community composition. Our analysis demonstrates that global policy targets align well with scientific understanding of marine biodiversity. Future efforts should focus on improving national‐level implementation and refining indicators to foster transformative change in biodiversity conservation.