In Arctic coastal lowland regions such as northernmost Alaska, thermokarst landscapes are often underlain by saline deposits, a factor frequently overlooked when assessing permafrost thaw risks. To evaluate the influence of thaw and salinity on organic matter degradation and landscape dynamics, we analyzed six sediment cores from representative landforms near Utqiaġvik (Alaska) using a multiproxy, carbon-focused approach, with emphasis on n-alkane biomarkers. Undisturbed tundra uplands contained well-preserved, organic-rich Holocene sediments (∼140 cm thick) overlying brackish late Pleistocene deposits, indicating the presence of saline permafrost. Thermokarst lake subsidence into these substrates led to enhanced organic matter degradation, as reflected by lower n-alkane carbon preference index (CPI) values. While West Twin Lake talik sediments exhibited brackish porewater, East Twin Lake sediments were characterized by predominantly saline porewater, indicating the presence of a cryopeg driven by salt-induced thaw-point depression. Lagoonal environments, receiving both terrestrial and lacustrine inputs, accumulate sediments under unfrozen hypersaline conditions, presenting a high potential for organic matter decomposition. Carbon proxy signatures statistically distinguish perennially frozen uplands, unfrozen lake sediments, refrozen drained lake basins, and lagoonal settings. Our results demonstrate that salt-bearing deposits, as found in all investigated sites, are vulnerable to active layer deepening, talik and cryopeg formation, and lake/coastal shoreline erosion. These processes accelerate organic matter degradation and alter landscape trajectories. Our study underscores the need to better understand the role of saline permafrost in Arctic coastal lowlands and its broader implications under ongoing climate change.