Compensating lipid fluxes generated by the aminophospholipid translocase


Contact
sfrickenhaus [ at ] awi-bremerhaven.de

Abstract

By a combined kinetic and thermodynamic model on the transbilayer dynamics and asymmetric distribution of lipids in the red blood cell, compensating lipid fluxes to the exoplasmic leaflet have been analysed, counterbalancing the active transport of aminophospholipids to the cytoplasmic monolayer by the aminophospholipid translocase. The compensating fluxes are assumed to be of passive naturegenerated by forces of lateral mechanical stress and of lipid concentration differences between the two monolayers.These forces are shown to be caused and maintained by the operation of the aminophospholipid translocase. Simulations reveal that a reduction of the compensating fluxes upon ATP-depletion can be attributed to the inhibition of the aminophospholipid translocase. Thus, a Mg(2+)- and ATP-dependence of the outward movement of phospholipid analogues in the plasma membrane of red blood cells can be expectedindependent of the existence and operation of an ATP-dependent 'floppase' activity.



Item Type
Article
Authors
Divisions
Programs
Peer revision
ISI/Scopus peer-reviewed
Publication Status
Published
Eprint ID
7325
Cite as
Frickenhaus, S. , Herrmann, A. and Heinrich, R. (1998): Compensating lipid fluxes generated by the aminophospholipid translocase , Molecular Membrane Biology, 15 , pp. 213-220 .


Share

Research Platforms
N/A

Campaigns


Actions
Edit Item Edit Item