When studying a complex system, it is often useful to think of the system as a network of interacting units. One can then ask if some properties of the entire network are already explained by a small part of the network, a network motif. A famous example of an ecological motif is exploitative competition in food webs, where the presence of two species competing for a shared resource precludes the existence of a stable equilibrium for the whole system. However, other examples of motifs with such direct impacts on stability are not known. Here, we show why small motifs that allow conclusions on systemic stability are rare. More importantly, we show that another dynamical property, reactivity, is typically rooted in motifs. Computing the reactivity of motifs can reveal which parts of a network are prone to respond violently to perturbations. This highlights motif reactivity as a useful property to measure in real-world systems to understand likely modes of systemic failure in food webs or other networks in epidemics, supply chains, or power grids.